TMS Treatment Outcomes

Literature Meta-Analysis


ONE-D Protocol (Vaughn et al. 2025)

Single-day TMS protocol using optimized neuroplastogen-enhanced techniques. Case series, n=32.

Response Rates Over Time

Remission Rates Over Time

HDRS-17 Score Trajectory

% Improvement (HDRS-17)

Week 12 Summary (All Measures)

ONE-D Raw Data

Brainsway Accelerated Protocol (ACC-iTBS vs Standard)

Non-inferiority RCT comparing accelerated iTBS protocol (2-week treatment) vs standard 6-week high-frequency protocol. n=104 (ITT).

Response Rates (HDRS)

Remission Rates (HDRS)

Response Comparison (HDRS & MADRS)

Remission Comparison (HDRS & MADRS)

Week 6 Summary

Onset of Remission (p=0.0324)

Brainsway Raw Data & Metadata

Ramos et al. 2025 aTBS (Sham-Controlled RCT)

Sham-controlled RCT comparing accelerated TBS (aTBS) vs sham stimulation. n=100 (50 per arm), 5-week treatment. JAMA Psychiatry 2025.

HDRS-17 Score Over Time

Response Rates (HDRS-17)

Remission Rates (HDRS-17)

MADRS Score Over Time

BDI Score Over Time (Self-Report)

Rate of Improvement (Slope)

Week 5 Summary (Response & Remission)

All Measures at Week 5

% Improvement (HDRS-17)

% Improvement from Baseline (All Measures)

Normalized improvement trajectory showing % reduction from baseline scores.

Secondary Endpoints & Adverse Events

Secondary Endpoints Analysis

Adverse Events (%)

Ramos Raw Data

Cole et al. 2022 — D-Cycloserine + iTBS (Sham-Controlled RCT)

Double-blind, placebo-controlled RCT comparing iTBS + d-cycloserine (100 mg) vs iTBS + placebo for MDD. n=47 (24 placebo, 23 DCS), 4-week treatment. JAMA Psychiatry 2022.

MADRS Score Over Time (Primary, p=.007)

CGI-Severity Over Time (p=.002)

CGI-Improvement (lower = better)

MADRS Points of Improvement

MADRS % Improvement from Baseline

Week 4 Summary (Key Measures)

% Improvement from Baseline (MADRS, CGI-S, QIDS-SR)

Normalized improvement trajectory showing % reduction from baseline scores.

Secondary Outcomes (QIDS-SR, GAD-7, VAS Well-Being)

DCS + TMS Raw Data

Primary Data (Patient-Level)

Individual Patient Trajectories

% Change from Baseline

Average % Change by Week

Median % Change by Week

Primary Data Table

Data Schemas

CSV Import Formats

primaryData

patient_id, protocol, scale, days, value

literatureData

study_name, study_type, year, measure, protocol, outcome, baseline, week_1, ...